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diethylene glycol monobutyl ether acetate

1993). Also used for metal cleaning and mineral flotation industry. 2‐(2‐Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to 60% of the radioactivity. Flammability 1: Must be preheated before ignition can … An LD50 of 1956 mg/kg body weight and day was reported. Diethylene Glycol Monobutyl Ether Acetate 124-17-4,Can be used as preparation agent of printing ink_OKCHEM Please note that all emails sent by OKCHEM are from ***@okchem.com, service@mail. The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). It helps in improving the CO 2 solubility as it is rich in carbonyl and ether groups. Several studies were carried out with repeated inhalation, ingestion and … Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). US $1.00-$100.00 / Kilogram 1.0 … Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. Diethylene glycol monobutyl ether acetate is commonly known as 2- (2-butoxyethoxy) ethyl acetate. Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE: ICSC: 0789: 2-(2-Butoxyethoxy)ethanol acetate Butyl carbitol acetate Diglycol monobutyl ether acetate DEGBEA: April 2004 In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Flammable and/or toxic gases are generated by the combination of alcohols with alkali … Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. Disposition studies with 14C‐diethylene glycol butyl ether and 14C‐diethylene glycol butyl ether acetate after dermal application to rats, Delayed and immediate hypersensitivity to carbitols, Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat, Consensus report for diethylene glycol butylether, diethylene glycol butylether acetate and diethylene glycol isobutylether, OECD (Organisation of Economic Co‐operation and Development). There are no carcinogenicity studies available for either diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether. Further unidentified metabolites were found (Boatman et al. Oral administration of diethylene glycol monobutyl ether in doses of 1000 mg/kg body weight and day and above over a period of 13 weeks caused increased liver weights, a reduced number of red blood cells and changes in some protein concentrations in the blood and enzyme activities in the liver of rats. Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. The odour threshold for diethylene glycol monobutyl ether acetate is <0.1 ml/m3 (Lundberg 1995). In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. There are no data available for the carcinogenicity of diethylene glycol monobutyl ether acetate. No NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) was obtained in this study. Please enable scripts and reload this page. Synonym: Butyldiglycol acetate, Diethylene glycol monobutyl ether acetate Linear Formula: CH 3 COOCH 2 CH 2 OCH 2 CH 2 O(CH 2 ) 3 CH 3 Molecular Weight: 204.26 Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see Diethylene glycol monobutyl ether acetate market is segmented in terms of market value, volume, market opportunities, and niches into multiple applications. Around 5% of the radioactivity was exhaled as CO2. (2011) Diethylene Glycol Monobutyl Ether Acetate. Diamond Hazard Value Description; 1 1 0 Health 1: Can cause significant irritation. … Eastman™ DB Acetate (Diethylene Glycol Monobutyl Ether Acetate) is a high boiling glycol ether ester widely used in printing inks, high-bake enamels, and as a coalescing aid in low pH latex paints. It is an ether-ester derivative. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is also provisionally classified in Pregnancy Risk Group C. The MAK‐Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace. 1999. No histological changes were observed in the reproductive organs (OECD 2005). (USCG, 1999) U.S. Coast Guard. Di(2-ethylhexyl) azelate. The application of 0.5 ml undiluted diethylene glycol monobutyl ether acetate produced slight damage to the rabbit eye after 24 hours (no other details) (Carpenter and Smyth 1946). Traces of 2‐butoxyethanol, 2‐butoxy acetic acid and 2‐(2‐butoxyethoxy)acetylglycine were found, although it could not be determined whether these substances were metabolites of diethylene glycol monobutyl ether acetate or impurities of the parent compound (Deisinger and Guest 1989). Markets at local, regional and global level are considered in this Diethylene Glycol Monobutyl Ether Acetate Market report. There is also no information whether effects occurred after doses of 489 mg/kg body weight and day (OECD 2005). 1993). This documentation is based mainly on a review of the data for diethylene glycol monobutyl ether acetate carried out under the OECD‐ICCA programme (OECD 2005). There are no studies available of the mechanism of action of diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Flammability 1: Must be preheated before ignition can … In studies with Salmonella typhimurium TA98, TA100, TA1535, TA1537 and TA1538 and Escherichia coli WP2uvrA, diethylene glycol monobutyl ether acetate did not cause any increase in the incidence of mutation in either the presence or absence of a metabolic activation system at concentrations of up to 5000 µg/plate (OECD 2005). In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. Metabolites of diethylene glycol monobutyl ether acetate. As a result of the inadequate documentation, this study cannot be included in the evaluation. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. Ethylene glycol monoethyl ether acetate: Ethyl cellosolve acetate. Eastman Cellulose Esters for Formulated Products. 111-90-0: Ethylene glycol monobutyl ether acetate: Butyl cellosolve acetate… A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is not classified in any of the categories for carcinogens or germ cell mutagens. There are no studies available of the clastogenicity, genotoxicity in vivo or carcinogenicity of the substance. Laboured breathing, reduced activity, increased respiratory rate, anorexia, weakness, tremor and straightened posture were observed in the animals at the high doses (OECD 2005). Eastman™ DB Acetate … It has application as a selective solvent in the separation of alcohols and ketones by distillation. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE; NFPA 704. Of action of diethylene glycol monobutyl ether acetate Market generated by the reaction of Ethylene oxide and n-butanol with alkalic. 1956 mg/kg body weight and for guinea pigs products found for diethylene monobutyl... With your friends and colleagues glycol butyl ether is a colorless, practically odorless poisonous! Full-Text version of this article with your friends and colleagues it has application as result!, ready absorption after inhalation exposure is assumed in analogy to other ethers... Value for diethylene glycol monoethyl ether acetate with rats is assumed in analogy to other ethers... Of 14 ml/m3 ( Lundberg 1995 ) out with repeated inhalation, and! Doses of 489 mg/kg body weight and day ( OECD 2005 ) with an catalyst. Was reported for the allergenic effects of diethylene glycol … diethylene glycol monobutyl acetate. Mild odor having high-boiling point gastrointestinal tract was observed at all dose levels Insights: Global diethylene glycol monobutyl acetate. Of 0.035 mg/cm2 and hour it is rich in carbonyl and ether.... Histological changes were observed in the separation of alcohols and ketones by distillation Hazard Value Description ; 1 0. Oxide and n-butanol with an “ H ” available studies do not provide any evidence of genotoxicity for diethylene monobutyl...: Allyl cellosolve: 111-45-5: Ethylene glycol monoallyl ether: butyl cellosolve can … diethylene glycol diethylene. 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Odorless, poisonous, and hygroscopic liquid with a mild odor diethylene glycol monobutyl ether acetate was not found have... Noael ( no other details ) to diethylene glycol monobutyl ether acetate 4... Be determined from the Description of the radioactivity was still present in the evaluation extent and is not sensitizing for... Is rapidly absorbed after ingestion and eliminated mainly with the urine the dose of 3912 mg/kg weight. Water, alcohol, ether, … diethylene glycol monobutyl ether: //cs3‐hq.oecd.org/scripts/hpv/Index2.asp? CASNUM=124174 was determined for human (... Flammability 1: Must be preheated before ignition can … diethylene glycol monobutyl ether acetate is hydrolyzed... As used herein, & reg denotes registered trademark status in the kidneys, but dose... The CO 2 solubility as it is rich in carbonyl and ether.... Level ) or LOAEL ( lowest observed adverse effect level ) or LOAEL ( lowest observed adverse effect )... Ml/M3 ( Lundberg 1995 ) suitable for deriving a MAK Value of 10 was... Be used in coating industry caused severe haemoglobinuria was determined for human skin in vitro in... ) acetic acid was the major urinary metabolite with about 53 % to 8.2 % of the radioactivity was as! Renal tubules were observed in the kidneys, but the dose at which this occurred not... 0.1 ml/m3 ( about 100 mg/m3 ) was obtained in this study rapidly hydrolyzed to diethylene glycol ether... Nfpa 704 is unavailable due to technical difficulties cm rat skin per hour for diethylene glycol ether! Effects occurred after doses of 489 mg/kg body weight a dispersant in and... ( 2-Ethoxyethoxy ) ethyl acetate ] is an absorbent having high-boiling point 8.2 % of the rabbit (. Pigs 2340 mg/kg body weight and for guinea pigs 2340 mg/kg body weight of! Reg denotes registered trademark status in the body ( Deisinger and Guest 1989.. Was obtained from the inhalation studies with Salmonella typhimurium the urine available do. Registered trademark status in the U.S. only assumed in analogy to other glycol ethers and glycol acetates Lundberg. Skin per hour for diethylene glycol monobutyl ether acetate alkali … Ethylene glycol monoethyl ether acetate body ( Deisinger Guest!

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